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Zoledronate maintains fat mass in older osteopenic women.

This study found that zoledronate, a medication used for osteoporosis, helped prevent age-related fat mass loss in late postmenopausal women. This suggests a potential benefit beyond bone health, possibly influencing intermediary metabolism and contributing to longevity.

Reid IR, Horne AM, Mihov B, Stewart A, Bastin S, Gamble GD. Zoledronate Slows Weight Loss and Maintains Fat Mass in Osteopenic Older Women: Secondary Analysis of a Randomized Controlled Trial. Calcif Tissue Int. 2020 Apr;106(4):386-391. doi: 10.1007/s00223-019-00653-7. Epub 2020 Jan 2. PMID: 31897528 Clinical Trial.

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