RCT

Vitamin D Supplementation Eases Perimenopause Fatigue and Mood

This randomized, double-blind, placebo-controlled trial found that six months of vitamin D3 supplementation significantly improved both fatigue and mood in perimenopausal women with vitamin D deficiency compared with placebo. Multivariate analysis confirmed vitamin D supplementation as an independent predictor of these improvements, suggesting that correcting deficiency may be a practical first step for women experiencing early perimenopausal fatigue and mood changes.