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PauseAndFlourishMenopause Wellness Reviews & Guidance

RCT

Sleep Drug Studied in Menopause Transition

In this randomized controlled trial subgroup, daridorexant 50 mg improved sleep measures and daytime functioning in women aged 47-55 with insomnia disorder. The findings suggest that targeted insomnia treatment may help women in the menopause transition, though medication decisions should be individualized with a clinician.

Citation

Schaedel Z, Bakker TR, Bassetti C, Briasoulis O, Cassel P, Pain S, et al. Efficacy and safety of daridorexant for the treatment of insomnia disorder in women of menopausal transition age: Insights from a randomized controlled trial. Maturitas. 2026;206:108821. doi:10.1016/j.maturitas.2025.108821.

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