RCT
Shorter Romosozumab Course Non-Inferior for Postmenopausal Bone Loss
This non-inferiority randomized controlled trial published in The Lancet found that three months of romosozumab produced bone mineral density gains at the total hip that were non-inferior to the standard twelve-month course in postmenopausal women with osteoporosis. The findings suggest that a shorter treatment duration may be a viable option, potentially improving tolerability and adherence for women in early postmenopause who need bone-protective therapy.
Citation
Leder BZ, Ramchand SK, Jordan M, Ryan S, Patnaik A, Lee H, et al. 3 months vs 12 months of romosozumab for postmenopausal osteoporosis (LIDA): an open-label, non-inferiority, randomised controlled trial. Lancet Diabetes Endocrinol. 2026 Mar;14(3):216-222. doi:10.1016/S2213-8587(25)00319-5. PMID: 41621431.
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