Meta-Analysis

Red Clover Isoflavones Modestly Reduce Menopausal Hot Flashes

This GRADE-assessed systematic review and meta-analysis of nine randomized controlled trials found that red clover isoflavone supplementation produced a statistically significant small-to-moderate reduction in hot flash frequency compared with placebo in menopausal women. The results support red clover as a phytoestrogenic alternative for women seeking non-hormonal options to manage vasomotor symptoms, though individual response may vary.