RCT

Probiotic Reduces Hot Flashes, Anxiety in Perimenopause

A randomized controlled trial of 100 women found that Limosilactobacillus reuteri NCU-37 supplementation significantly reduced hot flashes, night sweats, anxiety, depression, and insomnia scores compared to placebo in women with leuprorelin-induced perimenopausal syndrome. The probiotic also improved hormone levels and beneficially shifted gut microbiota composition, suggesting a gut-hormone axis mechanism for symptom relief.