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PauseAndFlourishMenopause Wellness Reviews & Guidance

RCT

Polyphenol Mix Improved Oxidized LDL but Raised Lipids

In a randomized crossover trial, 90 mildly hypercholesterolemic postmenopausal women took a multi-polyphenol mix that lowered oxidized LDL after eight weeks but raised total cholesterol, LDL cholesterol, and triglycerides. Responses differed by metabolic phenotype, underscoring that these biomarker findings do not establish a general cardiovascular benefit.

Citation

García-Nicolás M, Jarrín-Orozco MP, Romo-Vaquero M, Carrascosa C, Avilés-Plaza F, Martínez-Villanueva M, Noguera JA, Ávila-Gálvez MÁ, Espín JC. Polyphenols increase circulating lipids but improve LDL particle quality and reduce LDL oxidation in postmenopausal women: metabotype- and age-dependent effects in a randomised, placebo-controlled crossover trial. Eur J Nutr. 2026 Jun 29;65(5):177. doi:10.1007/s00394-026-04027-2. PMID: 42371155.

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