Observational

Micronized Progesterone Improves Sleep Onset at Three Months

A retrospective observational study found that switching menopausal women from synthetic progestins to micronized progesterone significantly improved sleep induction and reduced nighttime awakenings at three months, though these benefits diminished by one year. Women without pre-existing sleep disorders experienced worsened sleep, suggesting that micronized progesterone's sedative effects via GABA receptors require careful patient selection and ongoing monitoring.