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PauseAndFlourishMenopause Wellness Reviews & Guidance

Meta-Analysis

Hormone Therapy May Ease Perimenopause Depression

This meta-analysis of 12 randomized trials found that menopausal hormone therapy was associated with a small reduction in depressive symptom severity among perimenopausal women. The effect was modest and evidence certainty was limited, so treatment decisions should be individualized with a clinician.

Citation

Li Y, Sun Y, Bi Y, Yang L, Xu Y, Wu H, Ma X. Efficacy and safety of menopausal hormone therapy for depressive symptoms in perimenopausal women: A systematic review and meta-analysis. J Affect Disord. 2026;409:121892. doi:10.1016/j.jad.2026.121892.

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