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Herbal Supplement Improves Sleep, Fatigue, and Mood in Perimenopause

This 28-day randomized, double-blind, placebo-controlled trial found that Khapregesic® (Khaya senegalensis) supplementation significantly improved psychological symptoms, fatigue, and sleep disturbances in postmenopausal women compared to placebo. While no group-wide effects were observed across the full cohort, subgroup analyses suggest this herbal preparation may offer a safe, well-tolerated option for managing common early perimenopause symptoms including mood changes, fatigue, and sleep disruption.

Lopresti AL, Smith SJ, Ferdinands FR. An examination into the safety and efficacy of Khapregesic®, a Khaya senegalensis preparation, on physical and psychological wellbeing in women experiencing menopausal symptoms: a randomised, double-blind, placebo-controlled trial. Front Reprod Health. 2026 Jun 2;8:1824321. doi: 10.3389/frph.2026.1824321. eCollection 2026.

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