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Fatigue and Mood Top Self-Reported Early Perimenopause Symptoms Globally

A cross-sectional digital survey of 17,494 women from 158 countries found that while hot flashes are the most widely recognized perimenopause symptom, women aged 35 and older most commonly self-reported fatigue, physical and mental exhaustion, and irritability as their actual experiences. This global data highlights a critical knowledge gap between expected and lived perimenopause symptoms, underscoring the need for better education around early-stage mood and energy changes.

Hedges MS, Hewings-Martin Y, Karam J, Castaneda R, Cunningham AC, Xu Y, Zhaunova L, Faubion SS, Shufelt CL. Global perspectives on perimenopause: a digital survey of knowledge and symptoms using the Flo application. Menopause. 2026 Jul 1;33(7):789-798. doi: 10.1097/GME.0000000000002730. PMID: 41603602.

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