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PauseAndFlourishMenopause Wellness Reviews & Guidance

RCT

Estetrol Reduces Hot Flashes in Phase 3 Trial

This phase 3 randomized trial found that estetrol significantly reduced the frequency and severity of moderate to severe hot flashes compared with placebo over 12 weeks. The findings add evidence for a prescription option for women with peak vasomotor symptoms, with individualized risk-benefit review still essential.

Citation

Simoncini T, Bouchard C, Cloes M, Taziaux M, Palacios S, de Medeiros SF, Vrabii V, Archer DF, Panay N. Estetrol (E4) for the treatment of moderate to severe vasomotor symptoms in postmenopausal women - Efficacy and safety results from the phase 3 E4COMFORT I multicenter, placebo-controlled study. Maturitas. 2026;209:108965. doi:10.1016/j.maturitas.2026.108965.

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