Review

Early HRT Initiation Shows Cardiovascular Benefits in Postmenopause

A comprehensive review of major trials and meta-analyses highlights that initiating hormone replacement therapy (HRT) within 10 years of menopause onset consistently demonstrates cardiovascular benefits. Conversely, delayed initiation may increase risks such as stroke, underscoring the critical role of timing, formulation, and administration route in optimizing cardiovascular health outcomes for early postmenopausal women.