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Dietary Lignans May Support Perimenopause Mood

This randomized controlled trial found that one month of dietary lignan supplementation significantly reduced depressive and anxiety symptoms in perimenopausal women. The study suggests gut microbiome conversion of plant compounds may play a role, but supplementation choices should be discussed with a healthcare professional.

Yang C, Zhang X, Bie J, Kang W, Sun G, Zhao Q, Li L, Hu Q. Gut microbiota drives dietary lignans to improve perimenopausal depression via activating hippocampal ERβ/GluN2A/PSD95 pathway. Pharmacol Res. 2026;227:108161. doi:10.1016/j.phrs.2026.108161.

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