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Combined Approaches May Better Address Perimenopausal Mood Symptoms

A network meta-analysis of 131 randomized trials involving 11,457 perimenopausal women found benefits across pharmacotherapy, acupoint stimulation, and psychotherapy for emotional symptoms. Combination approaches generally ranked better on several measures, but no single strategy was consistently superior across all outcomes.

Zhuang J, Zhou Y, Yu G, Cheng H, Chen X, Qian R. Pharmacotherapy, acupoint stimulation, and psychotherapy for perimenopausal women with anxiety, depression, and panic disorder: a systematic review and network meta-analysis of randomized controlled trials. Front Psychiatry. 2026 Jul 17;17:1845876. doi:10.3389/fpsyt.2026.1845876. PMID: 42539596.

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